Exploring Metalloenzymes for Drug Discovery and Catalyst Design

Our research combines inorganic techniques of metalloenzyme characterization along with cutting-edge biochemical methods to identify, explore and target “druggable” redox-active metalloenzymes. We elucidate structure-function relations in redox-active metalloenzymes and apply this knowledge towards the development of novel drug lead compounds. We also utilize the insights gathered from these studies to design new biocatalysts with high efficiency and broad substrate scope. Drawing from core disciplines of chemical biology, inorganic chemistry, biophysics and organic synthesis, students in Bhagi-Damodaran Lab receive broad, fundamental training in experimental and computational techniques ranging from small-molecule discovery to spectroscopy and electrochemistry to protein biochemistry to cell work. Students are encouraged to take multiple approaches to address scientific questions. 

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