Exploring Metalloenzymes for Drug Discovery and Catalyst Design
Our research combines inorganic techniques of metalloenzyme characterization along with cutting-edge biochemical methods to identify, explore and target “druggable” redox-active metalloenzymes. We elucidate structure-function relations in redox-active metalloenzymes and apply this knowledge towards the development of novel drug lead compounds. We also utilize the insights gathered from these studies to design new biocatalysts with high efficiency and broad substrate scope. Drawing from core disciplines of chemical biology, inorganic chemistry, biophysics and organic synthesis, students in Bhagi-Damodaran Lab receive broad, fundamental training in experimental and computational techniques ranging from small-molecule discovery to spectroscopy and electrochemistry to protein biochemistry to cell work. Students are encouraged to take multiple approaches to address scientific questions.
American Cancer Society Institutional Grant
Our lab was just awarded the Institutional Research Grant from American Cancer Society. This grant funds our research towards rewiring hypoxia signaling in cancer cells.
Liz and Hunter win the NIH Chemical Biology Training Grant
Congrats to Liz and Hunter for winning a spot on the NIH Chemical Biology Training grant. We are very proud of you. It has been a pandemic of funding for the group :)
Lab gets the NIH MIRA grant
Our lab has procured the MIRA grant from NIH that brings in $1.9 M for five years to fund our research on decoding and rewiring enzymatic redox signal transduction pathways. Congrats lab on such a fantastic achievement. We hope to make good use of the money!
Ambika wins 3M award!
Congratulations to Ambika for winning the 3M Non-Tenured Faculty award that will fund our research on rewiring redox signaling in microbes to combat Hospital Acquired Infections.
Welcome Sourav and Murphi!
We welcome Sourav Chatterjee and Murphi Williams to the lab! Sourav joins us as a postdoc and Murphi is in the lab as a Research Assistant until Aug. when she will begin her grad school at UMN chemistry. Read more about Sourav and Murphi in our Members tab.